Depending on which normal cells are recognized, this can cause a range of side effects, including organ damage. But in some people, it may be severe or life-threatening.Īlso, although CAR T cells are designed to recognize proteins that are found only on cancer cells, they can also sometimes recognize normal cells. Most people have a mild form of cytokine release syndrome. A sudden increase in their levels can cause: This syndrome is caused when the transferred T cells, or other immune cells responding to the new T cells, release a large amount of cytokines into the blood.Ĭytokines are immune substances that have many different functions in the body. So, it is important to know which signs to look for and what to do if you start to have problems.ĬAR T-cell therapy can cause a serious side effect known as cytokine release syndrome. The side effects you may have and how serious they are will depend on how healthy you are before treatment, your type of cancer, how advanced it is, the type of T-cell transfer therapy you are receiving, and the dose.ĭoctors and nurses cannot know for sure when or if side effects will occur or how they will affect you. T-cell transfer therapy can cause side effects, which people experience in different ways. Then, these selected lymphocytes are treated with substances that make them grow to large numbers quickly. Doctors test these lymphocytes in the lab to find out which ones best recognize your tumor cells. TIL therapy uses T cells called tumor-infiltrating lymphocytes that are found in your tumor.After these treatments, the T cells that were grown in the lab will be given back to you via a needle in your vein. Reducing your immune cells helps the transferred T cells to be more effective. During this time, you may have treatment with chemotherapy and, maybe, radiation therapy to get rid of other immune cells. The process of growing your T cells in the lab can take 2 to 8 weeks. T-cell transfer therapy is also called adoptive cell therapy, adoptive immunotherapy, and immune cell therapy. Both involve collecting your own immune cells, growing large numbers of these cells in the lab, and then giving the cells back to you through a needle in your vein. There are two main types of T-cell transfer therapy: tumor-infiltrating lymphocytes (or TIL) therapy and CAR T-cell therapy. T-cell transfer therapy is a type of immunotherapy that makes your own immune cells better able to attack cancer.
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